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Lithium citrate

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Lithium citrate
Names
Other names
Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.011.860 Edit this at Wikidata
EC Number
  • 213-045-8
RTECS number
  • TZ8616000
UNII
  • InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 checkY
    Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K checkY
  • InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    Key: WJSIUCDMWSDDCE-DFZHHIFOAV
  • [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
Properties
Li3C6H5O7
Molar mass 209.923 g mol−1
Appearance Odorless white powder
Melting point decomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302, H319
P305+P351+P338
Flash point N/A
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Lithium citrate (Li3C6H5O7) is a lithium salt of citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder.[1][2][3][4] There is extensive pharmacology of lithium, the active component of this salt.

History

[edit]

Lithium citrate was one of the lithium salts used to add lithium to drinks and water (lithia water) in the late 19th century and the early 20th century, when there was a general health craze for lithium with it believed to be a cure-all.[5] The soft drink 7Up was at one point named "7Up Lithiated Lemon Soda" when it was formulated in 1929 because it claimed to contain lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. In 1936 the federal government forced the manufacturer to remove a number of health claims, and because "lithium was not an actual ingredient", the name was changed to just "7 Up" in 1937.[6]: §2  Many sources repeat an incorrect version of the story where the name is "Bib-Label Lithiated Lemon-Lime Soda" and the removal happened in 1948 due to a Food and Drug Administration ban.[7][8]

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder.[9] It can be administered orally in the form of a syrup.[9]

References

[edit]
  1. ^ Medication description
  2. ^ "pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com". medbroadcast.com. Retrieved 2017-08-15.
  3. ^ "Medical use". Archived from the original on 2006-06-15. Retrieved 2006-07-29.
  4. ^ "Lithium: medicine to control mood disorders such as mania and bipolar disorder". nhs.uk. 2020-08-17. Retrieved 2022-08-25.
  5. ^ "Lithium: Proving Its Mettle for 50 Years". JAMA. 281 (24): 2271. 23 June 1999. doi:10.1001/jama.281.24.2271.
  6. ^ Lockhart, Bill; Brown, Bob (2024). "The Seven-Up Company and 7-Up Bottles The Real Story: A Look at the Myths, the Mystery, and the Magic" (PDF). Society for Historical Archaeology. Chapter 1 Chapter 2
  7. ^ Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.
  8. ^ "Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". Time, Inc. 2016-02-20. Retrieved 2024-12-11.
  9. ^ a b PubChem. "Lithium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-08.


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